Silenor (Doxepin)

Medication Information & Treatment Considerations

Silenor (doxepin) is a prescription medication that may be considered by a licensed psychiatric provider as part of a treatment plan when clinically appropriate. Treatment recommendations are based on an individual’s symptoms, medical history, treatment goals, and overall clinical evaluation. Silenor is a low-dose formulation of doxepin that works by affecting histamine activity in the brain, which plays a role in sleep regulation and wakefulness. Individual experiences with medication vary, and treatment outcomes depend on many factors unique to each person. Silenor is not a controlled substance and must be prescribed by a licensed psychiatric provider. Through Telemynd, medication may be prescribed following a secure virtual evaluation when clinically appropriate. Many insurance plans cover Silenor and generic doxepin options may be available. Some people may experience side effects such as drowsiness, dry mouth, dizziness, nausea, or fatigue. Your provider will monitor your response to treatment and make adjustments as needed.

Important Safety Information

Silenor may cause drowsiness and may impair alertness the following day in some individuals. Individuals beginning treatment should use caution when driving or performing activities that require full attention until they understand how the medication affects them. This medication may not be appropriate for everyone. Before starting or changing any medication, discuss potential risks, benefits, side effects, warnings, and drug interactions with your healthcare provider. For complete prescribing information, medication warnings, precautions, contraindications, drug interactions, and the FDA-approved Medication Guide, please review the current FDA-approved prescribing information for Silenor (doxepin).

Educational Notice

This content is provided for informational and educational purposes only and should not be considered medical advice, treatment recommendations, or a guarantee that any medication will be prescribed. Medication decisions are made by licensed healthcare providers following a comprehensive clinical evaluation and consideration of individual needs.

Last reviewed: June 2026. Prescribing information may change. Refer to the current FDA-approved labeling for the most up-to-date safety information.